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Accession Number ADA566405
Title Production and Characterization of a Novel OX40 Ligand for Clinical Use.
Publication Date Aug 2012
Media Count 12p
Personal Author A. D. Weinberg
Abstract The goals of the second year/phase of the DOD funded research, PC073499, have been accomplished. We produced two human versions of the OX40 ligand:trimer:Ig protein. The two protein constructs have different human trimer domains (TRAF2 and Matrillin-4), which confer differing folding patterns within the two-dimension structure of the protein. These two fully human OX40L:Ig fusion proteins were administered to non-human primates to test for in vivo activity. The OX40L:Ig fusion proteins showed potent biologic activity in vivo, but it was clear that the one with the TRAF2 trimer domain was superior. Therefore we are moving forward with OX40L:Ig fusion protein with the TRAF2 trimer domain with the ultimate hope of taking it to clinical trials in patients with prostate cancer.
Keywords Cells(Biology)
Clinical medicine
Clinical trials
In vivo analysis
Prostate cancer
T lymphocytes
Tumor immunotherapy

Source Agency Non Paid ADAS
NTIS Subject Category 57E - Clinical Medicine
Corporate Author Angov (Evelina), Bethesda, MD.
Document Type Technical report
Title Note Final rept. 15 Jul 2008-14 Jul 2012.
NTIS Issue Number 1307
Contract Number W81XWH-08-1-0436

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