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Accession Number ADA566336
Title Architecture and Performance Analysis of General Bio-Molecular Networks.
Publication Date Jan 2012
Media Count 17p
Personal Author W. W. Li
Abstract This project provided a detailed framework to describe the components, reactions, and internal and external connections of the cellular control systems, developed a stochastic model of the generalized biomolecular network and obtained an analytic approach for the solution of the stochastic molecular network. Specifically, we have (1) Derived a novel and explicit iterative method (both the forward iterative method and backward iterative method) to calculate the solution of the Network Chemical Master Equation (CME); (2) Completed the numerical analysis based on our novel method and simulation analysis based on the nature of the molecular network for an example; (3) The result from numerical analysis and simulation analysis is almost exact same, which confirmed the correction of our theoretical result; and (4) The time to calculate the solution of CME by using our method is about 10 times faster than the time to calculate it by using the standard method. Our method is expected to be much better, in terms of the running time, for the system with more molecules.
Keywords Biochemistry
Cellular control systems
Explicit iterative method
Mathematical models
Molecular biology
Network chemical master equation
Stochastic bio-molecular networks
Stochastic processes

Source Agency Non Paid ADAS
NTIS Subject Category 57F - Cytology, Genetics, & Molecular Biology
Corporate Author Texas Southern Univ., Houston.
Document Type Technical report
Title Note Final performance rept. 15 Apr 2010-14 Oct 2011.
NTIS Issue Number 1307
Contract Number FA9550-10-1-0128

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