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Accession Number ADA564935
Title Dementia Resulting from Traumatic Brain Injury: What Is the Pathology.
Publication Date Jul 2012
Media Count 9p
Personal Author A. I. Scher D. P. Perl R. Diaz- Arrastia S. Shively
Abstract Traumatic brain injury (TBI) is among the earliest illnesses described in human history and remains a major source of morbidity and mortality in the modern era. It is estimated that 2% of the US population lives with long-term disabilities due to a prior TBI and incidence and prevalence rates are even higher in developing countries. One of the most feared long-term consequences of TBIs is dementia, as multiple epidemiologic studies show that experiencing a TBI in early or midlife is associated with an increased risk of dementia in late life. The best data indicate that moderate and severe TBIs increase risk of dementia between 2-and 4-fold. It is less clear whether mild TBIs such as brief concussions result in increased dementia risk, in part because mild head injuries are often not well documented and retrospective studies have recall bias. However, it has been observed for many years that multiple mild TBIs as experienced by professional boxers are associated with a high risk of chronic traumatic encephalopathy (CTE), a type of dementia with distinctive clinical and pathologic features. The recent recognition that CTE is common in retired professional football and hockey players has rekindled interest in this condition, as has the recognition that military personnel also experience high rates of mild TBIs and may have a similar syndrome. It is presently unknown whether dementia in TBI survivors is pathophysiologically similar to Alzheimer disease, CTE, or some other entity. Such information is critical for developing preventive and treatment strategies for a common cause of acquired dementia. Herein, we will review the epidemiologic data linking TBI and dementia, existing clinical and pathologic data, and will identify areas where future research is needed.
Keywords Clinical medicine
Concussion
Dementia
Head(Anatomy)
High rate
Illness
Incapacitation
Long range(Time)
Mental disorders
Military personnel
Morbidity
Mortality rate
Reprints
Signs and symptoms
Traumatic brain injuries


 
Source Agency Non Paid ADAS
NTIS Subject Category 57E - Clinical Medicine
Corporate Author Uniformed Services Univ. of the Health Sciences, Bethesda, MD.
Document Type Journal article
Title Note N/A
NTIS Issue Number 1304
Contract Number N/A

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