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Accession Number ADA564541
Title Cyclin D1-AR Crosstalk: Potential Implications for Therapeutic Response in Prostate Cancer.
Publication Date Apr 2012
Media Count 9p
Personal Author M. Schiewer
Abstract Prostate cancer is dependent on androgens and the androgen receptor (AR) for disease initiation, maintenance, and progression. Through work by our group and others, it has been shown that there is significant crosstalk between AR and the cell cycle machinery. Most importantly for our study, AR has been shown to induce the G1 to S phase transition in part via regulation of cyclin D1. Cyclin D1 serves as a rheostat to temper the pro-proliferative signaling of AR by directly binding to the receptor and inhibiting it s activity, thus inducing cell cycle arrest. As such, the AR-cyclin D1 crosstalk axis may serve to control the proliferative capacity of prostate cancer cells, and potentially alter the therapeutic efficacy of anti-cancer drugs. The data presented herein will demonstrate that cyclin D1 status does not impinge on the biological outcome in vitro of taxane-based therapy.
Keywords Androgen receptor
Androgens
Cells(Biology)
Crosstalk
Diseases
Growth(Physiology)
In vitro analysis
Phase transformations
Prostate cancer
Receptor sites(Physiology)
Sense organs
Therapy


 
Source Agency Non Paid ADAS
NTIS Subject Category 57A - Anatomy
57S - Physiology
57E - Clinical Medicine
Corporate Author Thomas Jefferson Univ., Philadelphia, PA.
Document Type Technical report
Title Note Annual summary rept. 1 Apr 2011-31 Mar 2012.
NTIS Issue Number 1303
Contract Number W81XWH-10-1-0209

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