Accession Number ADA564521
Title Diet Restriction and Fasting Exacerbate the Toxicity of Soman in Young and Old Guinea Pigs.
Publication Date Sep 2012
Media Count 20p
Personal Author J. L. Langston T. M. Myers
Abstract This study evaluated the effects of age (60 vs. 150 days), diet restriction (ad libitum vs. 80%), and fasting (recently fed vs. fasted 18 h) on survival, toxic signs, body weight, blood glucose, carboxylesterase, acetylcholinesterase, and butyrylcholinesterase in male guinea pigs exposed acutely to 0, 0.6, or 1.0 LD50 soman subcutaneously. Following soman exposure, body weight decreased but recovered by 1 week. Acetylcholinesterase levels were significantly decreased at all post-exposure time points (up to 1 week). Butyrylcholinesterase levels were suppressed out to 48 h post-exposure, but recovered by 1 week. Toxic signs were more severe in diet-restricted animals than ad libitum animals. Young animals exhibited more severe signs of toxicity than old animals. All animals in the saline and 0.6 LD50 groups survived to 1 week. For the 1.0 LD50 groups, old animals exhibited significantly greater survival (44.4%) than young animals (16.7%). Ad-libitum animals had significantly longer mean survival (87.7 h) times than diet-restricted animals (55.5 h), demonstrating a toxicity-enhancing effect of diet restriction.
Keywords Acetylcholinesterase
Age
Blood chemistry
Body weight
Butyrates
Caloric restriction
Cholinesterase
Diet
Fasting
Food deprivation
Gd agent
Glucose
Guinea pigs
Salinity
Signs and symptoms
Soman toxicity
Suppression
Toxicity


 
Source Agency Non Paid ADAS
NTIS Subject Category 57B - Biochemistry
57L - Nutrition
98H - Food Technology
57Y - Toxicology
Corporate Author Army Medical Research Inst. of Chemical Defense, Aberdeen Proving Ground, MD.
Document Type Technical report
Title Note Technical rept. 1 Mar-30 Sep 2005.
NTIS Issue Number 1303
Contract Number N/A

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