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Accession Number ADA564469
Title Development of a Hybrid Optical Biopsy Probe to Improve Prostate Cancer Diagnosis.
Publication Date Jun 2010
Media Count 15p
Personal Author H. Liu
Abstract Hypothesis: a multi-modal optical spectroscopic method and an integrated needle probe can be developed for guiding needle biopsy for prostate cancer diagnosis. Multi-modal optical measurements to be utilized for the study are (1) light scattering spectroscopy (LSS), (2) auto-fluorescence spectroscopy (AFS), and (2) auto-fluorescence life-time measurements (AFLT). Our specific aims are: Aim 1: to develop a multi-modal, optical spectroscopic instrument, which allows the measurements of (1) LSS, (2) AFS, and (3) AFLT. The proposed system will be portable, can be used for in vivo measurements, and collect and present the data in real time. Aim 2: to integrate the optical fibers, which collect light scattering and auto-fluorescence from the prostate tissue, into a transrectal-ultrasound, needle-biopsy probe. In the development phase, the optical signatures of prostate cancer can be collected with the biopsy tissues and identified along every tract of needle biopsies. Aim 3: to collect optical signals of control and cancer tissues ex vivo along with the regular human needle biopsy, followed by classification algorithm development to discriminate cancer tissues. Aim 4: to perform in vivo measurement from human subjects to obtain the accuracy and sensitivity of the integrated probe in order to provide real-time, on-site, improved guidance for prostate cancer tissue biopsy.
Keywords Auto-fluorescence spectroscopy
Fiber optics transmission lines
Fluorescence life-time measurement
In vivo analysis
Integrated systems
Life span(Biology)
Optical biopsy
Optical equipment
Optical properties
Optical signatures
Optical spectroscopy
Prostate cancer
Prostate gland
Technology development
Transrectal probe

Source Agency Non Paid ADAS
NTIS Subject Category 57E - Clinical Medicine
46C - Optics & Lasers
Corporate Author Texas Univ. at Arlington.
Document Type Technical report
Title Note Annual rept. 1 Jun 2009-31 May 2010.
NTIS Issue Number 1303
Contract Number W81XWH-09-1-0406

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