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Accession Number ADA564326
Title Lung Cancer Prevention Through Prophylactic Vaccination Against Endogenous Retroviral Antigens.
Publication Date Sep 2011
Media Count 13p
Personal Author H. Levitsky
Abstract No form of disease prevention has had greater success than prophylactic immunization. Whereas therapeutic cancer vaccines have only marginal evidence of clinical efficacy, prophylactic vaccination against tumor- associated antigens can confer life-long protection in both transplantable and transgenic cancer models. Yet most non-virally associated cancers lack candidate antigens that could be targeted for human cancer prevention. Endogenous Retroviral sequences and other transposable elements (TEs) comprise almost 40% of the human genome. These remnants of exogenous retroviruses are crippled through mutation and do not make infectious virus. Furthermore, promoter and histone modification silence their expression. Nevertheless, many cancers express them as a result of altered gene regulation, and the proteins they encode are recognizable as neo-antigens in both mouse and man. We have created repeat sequence arrays for the mouse and human genomes. Using mouse lung cancer models and human clinical samples, we are defining the pattern and kinetics of TE expression during neoplastic transformation. We seek to determine if endogenous immune responses to such antigens may lead to early detection, and if prophylactic vaccination delays or prevents the onset of lung cancer in mouse models.
Keywords Antigens
Clinical medicine
Genes
Histones
Immunity
Immunization
Infectious diseases
Lung cancer
Pathogenesis
Preventive medicine
Prophylactic vaccination
Proteins
Repeat sequence arrays
Response(Biology)
Retroviruses
Sampling
Transformations
Transposable elements
Viruses


 
Source Agency Non Paid ADAS
NTIS Subject Category 57E - Clinical Medicine
Corporate Author Johns Hopkins Univ., Baltimore, MD.
Document Type Technical report
Title Note Final rept. 15 Aug 2010-14 Aug 2011.
NTIS Issue Number 1303
Contract Number W81XWH-10-1-0631

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