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Accession Number ADA564322
Title Descriptive Biomarkers for Assessing Breast Cancer Risk.
Publication Date Oct 2011
Media Count 9p
Personal Author K. F. Arcaro
Abstract The purpose of this research is to determine the extent to which exfoliated epithelial cells present in breast milk can be used to assess a woman s individual risk of developing breast cancer and to detect early signs of the disease. To accomplish this goal we collected breast milk samples from 250 lactating women who either have had a breast biopsy or were scheduled for a breast biopsy. We isolated the epithelial cells and completed DNA promoter methylation analysis of the proposed tumor suppressor genes. We presented results of our research at several scientific meetings and published a paper in Epigenetics demonstrating increased promoter methylation in cells from the breast milk of women at increased risk of developing breast cancer. While the study has concluded we continue with annual follow-up on all women who donated breast milk. A second manuscript describing the results for additional tumor suppressor genes is in preparation and additional studies are being conducted with the archived milk samples.
Keywords Biopsy
Breast cancer
Breast milk
Deoxyribonucleic acids
Mammary glands
Promoter hypermethylation
Tracer studies

Source Agency Non Paid ADAS
NTIS Subject Category 57E - Clinical Medicine
Corporate Author Massachusetts Univ., Amherst.
Document Type Technical report
Title Note Final rept. 15 Sep 2008-14 Sep 2011.
NTIS Issue Number 1303
Contract Number W81XWH-08-1-0721

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