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Accession Number ADA564160
Title Role of Receptor Sialylation in the Ovarian Tumor Cell Phenotype.
Publication Date Jun 2012
Media Count 8p
Personal Author S. L. Bellis
Abstract The overarching goal of our research is to define the role of a cancer-associated glycosyltransferase, ST6Gal-I, in regulating the ovarian tumor cell phenotype. In the first year of this pilot project, significant progress has been made toward establishing ST6Gal-I s function in protecting tumor cells from apoptosis. These results establish a new paradigm in apoptotic signaling, particularly given that there is a marked dearth of evidence concerning glycosylation-dependent mechanisms in tumor cell survival. We also show that tumor cells can be sensitized to cisplatin-induced cell death through forced downregulation of ST6Gal-I. Platin drugs represent a first-line treatment for ovarian cancer, therefore therapeutic targeting of ST6Gal-I may hold promise for treating patients that have become chemoresistant. Finally, preliminary results indicate that ST6Gal-I protein is upregulated in human ovarian tumors, implicating ST6Gal-I as a potential new biomarker. In the upcoming year, our studies will focus on elucidating the mechanistic basis by which ST6Gal-I modulates the activity of integrins and death receptors to control tumor cell invasion and apoptosis-resistance.
Keywords Apoptosis
Death receptors
Metastasis disease
Ovarian cancer
Ovarian cancer cells
Receptor sites(Physiology)
Sialic acids

Source Agency Non Paid ADAS
NTIS Subject Category 57E - Clinical Medicine
57B - Biochemistry
Corporate Author Alabama Univ. in Birmingham.
Document Type Technical report
Title Note Annual rept. 15 May 2011-14 May 2012.
NTIS Issue Number 1302
Contract Number W81XWH-11-1-0404

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