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Accession Number ADA564159
Title Potential Use of Glycine to Enhance Radiation Therapy for Prostate Cancer.
Publication Date May 2012
Media Count 7p
Personal Author B. Kavanaugh
Abstract The project is intended to determine whether a specific nitric oxide- mediated tumor stress response pathway that is initiated following a cytotoxic injury (1) is observed in prostate cancer xenografts and (2) can be inhibited by the administration of dietary glycine supplementation. The rationale is based upon prior preclinical studies establishing, for other solid tumor types, that upregulation of inducible nitric oxide synthase (iNOS) in activated macrophages recruited to the site of cytotoxic injury from radiation or chemotherapy leads to the production of NO that stabilizes hypoxia-inducible factor 1-alpha, which in turns leads to increased expression of vascular endothelial growth factor (VEGF). As a result of this signaling process, tumor angiogenesis is supported, leading to recovery from the initial cytotoxic injury. It is believed that inhibiting this NO-mediated process of angiogenesis can enhance the cytotoxicity of radiation or chemotherapy, and it is believed that glycine might be an effective.
Keywords Angiogenesis
Chemotherapy
Cytotoxins
Glycine
Hypoxia
Neoplasms
Nitrates
Nitric oxide
Pathology
Prostate cancer
Radiation
Radiotherapy
Surgical transplantation
Synthases
Vegf(Vascular endothelial growth factor)
Wounds and injuries


 
Source Agency Non Paid ADAS
NTIS Subject Category 57E - Clinical Medicine
57V - Radiobiology
Corporate Author Colorado Univ., Aurora.
Document Type Technical report
Title Note Annual rept. 1 May 2011-30 Apr 2012.
NTIS Issue Number 1302
Contract Number W81XWH-11-1-0363

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