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Accession Number ADA564140
Title T-pharmacytes for Prostate Cancer Immunotherapy.
Publication Date Jun 2012
Media Count 4p
Personal Author D. Irvine J. Chen K. Wittrup
Abstract The goal of this project is to engineer T-cells for adoptive cell therapy of prostate cancer, by conjugating drug-loaded nanoparticles to therapeutic cells to enable targeted drug delivery to tumor sites and lymph nodes. Nanoparticles with cytokine proteins bound to their surfaces will be attached to the surface of T-cells the equivalent of delivering a drugloaded pill to each individual anti-tumor T-cell. These drug-carrying T-Pharmacytes will be continuously stimulated by the protein and carry these cytokine-loaded particles wherever they traffic in the body. We hypothesize that this strategy will provide a safe and effective means to augment adoptive cell therapy and allow the great promise of this immunotherapy to be realized for treatment of prostate cancer. The proposed studies will provide a preclinical test of this concept. If successful, this approach to enhancing an immunotherapy strategy already in clinical trials might be translated to patient treatment in a relatively short timespan.
Keywords Cells(Biology)
Cytokines
Immunotherapy
Lymph nodes
Neoplasms
Prostate cancer
Proteins
Therapy

 
Source Agency Non Paid ADAS
NTIS Subject Category 57E - Clinical Medicine
Corporate Author Massachusetts Inst. of Tech., Cambridge.
Document Type Technical report
Title Note Annual rept. 15 May 2011-14 May 2012.
NTIS Issue Number 1302
Contract Number W81XWH-10-1-0291

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