Accession Number ADA564121
Title Toxic Effects of Lead and Electromagnetic Pulse Energy on Memory Mechanisms.
Publication Date Aug 2012
Media Count 23p
Personal Author D. S. Ling E. Moshang L. Yang R. G. Riechers
Abstract Traumatic brain injury (TBI) due to explosive blast is a signature wound of combat operations, but the etiology of blast TBI is still not fully elucidated. The goal of this study was to determine whether low-level electromagnetic pulse (LEMP) energy, alone or in combination with lead (Pb), disrupts the physiological mechanisms of memory, and thus represents a potential neuropathogenic factor of explosive blasts. We examined the effects of LEMP and Pb on long-term potentiation (LTP), which is thought to be a key process of memory, using acutely prepared slices of rat hippocampus. A mathematical model of blast-generated LEMP was developed to estimate the EM energy received by the brain from a 10 kg blast from a 10 m distance and then scale the values for brain slices. An EM pulse generation system was used to expose slices to these LEMP values. In the absence of Pb, we found that single, brief (1 ms) exposures to 800 MHz or 1000 MHz LEMP significantly inhibited LTP induction, whereas 650 MHz LEMP had no effect. However, in the presence of low- level Pb (10 uM), 650 MHz LEMP effectively blocked LTP. These results suggest that LEMP may represent a pathogenic factor of blast TBI, and that low levels of Pb may increase neural susceptibility to LEMP.
Keywords Brain slices
Electromagnetic pulses
Electrophysiology
Hippocampus
Lead compounds
Lead(Metal)
Lemp(Low level electromagnetic pulse)
Ltp(Long term potentiation)
Mathematical models
Memory(Psychology)
Neuropathogenic factors
Rats
Synaptic transmissions
Traumatic brain injuries


 
Source Agency Non Paid ADAS
NTIS Subject Category 57A - Anatomy
57S - Physiology
57E - Clinical Medicine
79E - Detonations, Explosion Effects, & Ballistics
Corporate Author State Univ. of New York Downstate Medical Center, Brooklyn.
Document Type Technical report
Title Note Final rept. 30 Sep 2010-29 Mar 2012.
NTIS Issue Number 1302
Contract Number FA9550-10-1-0547

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