Accession Number ADA563970
Title Biomimetic Nanosensor Arrays for Selective Small Molecule Detection.
Publication Date Feb 2012
Media Count 14p
Personal Author M. McAlpine
Abstract Molecular biomimetics is an emerging field in which the tools of molecular biology and nanotechnology are synergized. One area of vital relevance is chemical and biological sensing, which if implemented on biocompatible substrates, could yield breakthroughs in implantable or wearable monitoring systems. Biomimicking smart materials which integrate chemical recognition moieties with sensitive transducers could provide a general platform for highly specific analyte sensors. Nanomaterials are particularly sensitive chemical sensors because of their high surface-to-volume ratios. Our research has focused on the bio-functionalization of nanoscale materials to yield sensors which mimic the olfactory system.1-5 Likewise, oligopeptides are robust substrates for the selective recognition of a variety of chemical and biological species. Our current research is focused on bio-inspired approaches to mimicking olfaction by linking peptides to nanosensors for the selective detection of biological species ranging from small molecules to pathogens. The peptide/nanowire sensors are designed, via combinatorial peptide engineering, to exhibit highly selective responses to a range of target analytes, and to detect traces of these gases from chemically camouflaged mixtures. We anticipate that this program will reveal fundamental understandings of the relative contributions of inter-molecular reactivity and structural identification in the function of olfactory protein receptors. Furthermore, the unique capability to tailor odorant sensing should enable transformational opportunities in environmental and medical applications.
Keywords Amino acids
Arrays
Biomimetics
Chemical detection
Gases
Hybrid systems
Identification
Medicine
Mixtures
Molecules
Oligomers
Peptides
Recognition
Structural properties
Substrates
Tools


 
Source Agency Non Paid ADAS
NTIS Subject Category 99D - Basic & Synthetic Chemistry
99C - Polymer Chemistry
99F - Physical & Theoretical Chemistry
Corporate Author Princeton Univ., NJ. Office of Research and Project Administration.
Document Type Technical report
Title Note Final technical rept. 1 Mar 2009-30 Nov 2011.
NTIS Issue Number 1301
Contract Number FA9550-09-1-0096

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