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Accession Number
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ADA562459
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Title
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Electrode Array Development for Recovery of Stepping Following Spinal Cord Injury.
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Publication Date
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Dec 2010
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Media Count
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11p
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Personal Author
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V. R. Edgerton
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Abstract
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We have designed and fabricated flexible electrode array system and demonstrated that the epidural stimulating arrays work better and can facilitate locomotion significantly earlier after spinal cord injury than conventional wire epidural stimulating electrodes. We have been able to maintain a functional, implanted array in a complete spinal rat for 6 weeks. We found stable parameters of the electrode array (impedance of electrodes and thresholds of evoked responses) for this period and observed stable rhythmic hindlimb activity facilitated with stimulation from selected electrode combinations. We also found that stimulation with the epidural electrode array could selectively activate spinal pathways responsible for monosynaptic and polysynaptic responses that may provide new perspectives in the assessment of the spinal cord after injury.
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Keywords
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Cordage
Electrical stimulation
Electrodes
Implantation
Locomotion
Spinal column
Spinal cord
Wounds and injuries
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Source Agency
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Non Paid ADAS
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NTIS Subject Category
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57E - Clinical Medicine
57M - Occupational Therapy, Physical Therapy, & Rehabilitation
95C - Biomedical Instrumentation & Bioengineering
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Corporate Author
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California Univ., Los Angeles.
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Document Type
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Technical report
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Title Note
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Final rept. 18 Mar 2009-17 Nov 2010.
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NTIS Issue Number
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1225
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Contract Number
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W81XWH-09-2-0024
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