Accession Number ADA560268
Title Neural and Behavioral Sequelae of Blast-Related Traumatic Brain Injury.
Publication Date Sep 2011
Media Count 6p
Personal Author S. M. Rao
Abstract Traumatic brain injuries (TBI) are a common occurrence from roadside blasts of improvised explosive devices (IEDs). In the proposed cross-sectional study, we aim to apply neurobehavioral testing and advanced MRI techniques task-activated functional MRI (fMRI) and diffusion tensor imaging (DTI) to gain a comprehensive understanding of the neural changes underlying blast- related MTBI. We will accomplish this goal by conducting advanced neuroimaging (task-activated fMRI and DTI fiber tracking) and neurobehavioral testing (computerized assessment and standard neuropsychological testing) on 60 chronic trauma patients: 15 military MTBI patients who have experienced blast injuries, 15 civilian MTBI patients with mechanical closed head injuries, 15 military and 15 civilian patients with orthopedic injuries. Year one of the project has been devoted to the development of the necessary infrastructure for the execution of this complex multisite study. A number of development tasks have been undertaken, including hiring and training a new coordinator in Houston, developing uniform procedures for analysis of image data in Cleveland and Houston, and further developing the avenues for recruitment of subjects. We have recruited 32 subjects and acquired imaging and cognitive data from 25 of these subjects. We are satisfied that the accrual of data is of high reliability and integrity. Over the next year, we will continue recruitment, acquisition of data, and data analysis across the two study sites.
Keywords Blast
Blast-related traumatic brain injury
Cognition
Dti(Diffusion tensor imaging)
Fmri(Functional magnetic resonance imaging)
Magnetic resonance imaging
Neurology
Psychology
Traumatic brain injuries


 
Source Agency Non Paid ADAS
NTIS Subject Category 92B - Psychology
57T - Psychiatry
57E - Clinical Medicine
Corporate Author Cleveland Clinic Foundation, OH.
Document Type Technical report
Title Note Annual rept. 1 Sep 2010-31 Aug 2011.
NTIS Issue Number 1221
Contract Number W81XWH-08-2-0124

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