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Accession Number
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ADA559325
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Title
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Mechanism-Based Enhanced Delivery of Drug-Loaded Targeted Nanoparticles for Breast Cancer Therapy.
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Publication Date
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Feb 2012
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Media Count
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13p
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Personal Author
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T. Bronich
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Abstract
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This Synergistic IDEA project seeks to develop a novel strategy to effectively target ErbB2-overexpressing breast cancer with anti-ErbB2 antibody coated nanogels carrying potent chemotherapeutics in combination with HSP90 inhibitors to enhance the endocytosis of ErbB2-receptor bound nanogel cargo. A successful outcome of our studies will provide a new therapeutic approach against a particularly difficult form of breast cancer and may provide a template for therapeutic targeting of other forms of breast cancer and other cancers. Success in preclinical models would also provide strong rationale for clinical translation of this technology with the ultimate goals of selective delivery of imaging and therapeutic modalities to tumors. Robust procedures for the synthesis of nanogels were developed, key structural parameters of block copolymers governing the physicochemical properties of the nanogels were identified, nanogels loaded with combination of anticancer therapeutics and methods for the preparation of ErbB2-targeted nanogels were developed, Mannose functionalized BICs provided a safe and stable platform for gene delivery to macrophages, doxorubicin-nanogels showed an efficient systemic drug delivery to human tumor xenografts.
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Keywords
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Breast cancer
Chemotherapy
Clinical medicine
Copolymers
Doxorubicin
Drugs
Erbb2 overpressing
Genes
Mannose
Monoclonal antibodies
Nanoparticles breast cancer therapy
Neoplasms
Physicochemical properties
Potency
Stabilized platforms
Structural properties
Surgical transplantation
Synergism
Synthesis
Templates
Therapy
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Source Agency
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Non Paid ADAS
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NTIS Subject Category
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57E - Clinical Medicine
57Q - Pharmacology & Pharmacological Chemistry
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Corporate Author
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Nebraska Univ. at Omaha.
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Document Type
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Technical report
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Title Note
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Annual rept. 18 Jan 2011-17 Jan 2012.
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NTIS Issue Number
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1219
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Contract Number
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W81XWH-11-1-0167
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