Accession Number ADA559272
Title Development of a Hybrid Optical Biopsy Probe to Improve Prostate Cancer Diagnosis.
Publication Date Jun 2011
Media Count 8p
Personal Author H. Liu
Abstract Hypothesis: a multi-modal optical spectroscopic method and an integrated needle probe can be developed for guiding needle biopsy for prostate cancer diagnosis. Multi-modal optical measurements to be utilized for the study are (1) light scattering spectroscopy (LSS), (2) auto-fluorescence spectroscopy (AFS), and (2) auto-fluorescence life-time measurements (AFLT). Our specific aims are: Aim 1: to develop a multi-modal, optical spectroscopic instrument, which allows the measurements of (1) LSS, (2) AFS, and (3) AFLT. The proposed system will be portable, can be used for in vivo measurements, and collect and present the data in real time. Aim 2: to integrate the optical fibers, which collect light scattering and auto-fluorescence from the prostate tissue, into a transrectal-ultrasound, needle-biopsy probe. In the development phase, the optical signatures of prostate cancer can be collected with the biopsy tissues and identified along every tract of needle biopsies. Aim 3: to collect optical signals of control and cancer tissues ex vivo along with the regular human needle biopsy, followed by classification algorithm development to discriminate cancer tissues. Aim 4: to perform in vivo measurement from human subjects to obtain the accuracy and sensitivity of the integrated probe in order to provide real-time, on-site, improved guidance for prostate cancer tissue biopsy.
Keywords Aflt(Auto fluorescence life timemeasurements)
Auto-fluorescence spectroscopy
Biopsy
Diagnosis(Medicine)
Fiber optics transmission lines
Fluorescence life-time measurement
Hybrid systems
Hypotheses
In vivo analysis
Integrated systems
Life span(Biology)
Light scattering
Lss(Auto fluorescence spectroscopy)
Optical biopsy
Optical equipment
Optical instruments
Optical properties
Optical spectroscopy
Prostate cancer
Prostate gland
Spectroscopy
Technology development
Tissues(Biology)
Transrectal probe


 
Source Agency Non Paid ADAS
NTIS Subject Category 57E - Clinical Medicine
95C - Biomedical Instrumentation & Bioengineering
44H - Health Care Technology
46C - Optics & Lasers
Corporate Author Texas Univ. at Arlington.
Document Type Technical report
Title Note Annual rept. 1 Jul 2010-31 May 2011.
NTIS Issue Number 1219
Contract Number W81XWH-09-1-0406

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